Cancer is a disease that originates from a single cell that grows out of control. Cancer cells can bypass the most basic cellular checks and balances because of abnormal genes. These cells exploit cellular mechanisms that are normally strictly regulated to keep an organism in balance.
This learning program is designed to introduce you to the basic principles of cancer biology, with a focus on the multistage process of cancer. The program begins with an overview of the nature of cancer, including its definition and etiology, followed by in-depth presentations on the molecular and cellular biology of cancer. You will learn about the origins of cancer in normal tissue and its progressive nature in the body. You will also learn about the body’s defenses and the repair mechanisms that normally prevent cancer development.
Upon completion of this learning program, you will be able to::
Provide a broad definition of cancer.
Identify the 2 main gene categories involved in cancer progression.
Discuss the role of mutations in oncogenesis and list the primary causes of mutations.
Describe the cancer hallmarks that give rise to tumor growth.
Explain the cellular mechanisms that allow cancer invasion and metastasis.
The Nature Of Cancer
Definition Of Cancer
Etiology Of Cancer At A Glance
Popup: 1890 To 1910
Popup: 1930 To 1950
Popup: 1950 To 1970
Popup: 1970 To 1990
Popup: 1990 To 2010
Popup: 2010 To 2020
Molecular Biology Of Cancer
Side Note: Digging Deeper – List Of Common Oncogenes
Tumor Suppressor Genes
Side Note: Digging Deeper – List Of Common Tsgs
Mechanisms Of Oncogene Activation And Tsg Inactivation
Dna Repair And Genetic Instability
Popup: Base Excision Repair
Popup: Nucleotide Excision Repair
Popup: Nonhomologous End-joining
Popup: Homologous Recombination
Popup: Point Mutations
Popup: Amplifications And Deletions
Popup: Whole Chromosome Gain Or Loss
Popup: Uv Light
Popup: Ionizing Radiation
Cellular Biology Of Cancer
Sustaining Proliferative Signaling
Evading Growth Suppressors
Enabling Replicative Immortality
Deregulating Cellular Energetics
Side Note: Digging Deeper – The Warburg Effect
Cancer Invasion And Metastasis
What Is Angiogenesis?
Activating Invasion And Metastasis
Extravasation And Intravasation
Side Note: Digging Deeper – Main Sites Of Metastasis